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These effects were amplified by selective erythropoiesis activation and inhibited by the ferroptosis inhibitor liproxstatin-1, indicating that Jak2VF signaling accelerates AS by promoting macrophage ferroptosis and erythrocyte phagocytosis ( 5.3 Ferroptosis of vascular smooth muscle cells promotes atherosclerosis Vascular smooth muscle cells (VSMCs) are essential in the early and advanced stages of AS

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Furthermore, a high-protein diet markedly elevates the level of the phenylalanine derivative PAGln produced by the gut microbiota, exacerbating colitis symptoms in mouse models

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